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KMID : 0365819690090020037
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Journal of Pusan Medical College
1969 Volume.9 No. 2 p.37 ~ p.41
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A Case of Weber-Christian Disease
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Abstract
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A 58 year-old Korean women came to the Out-Patient Clinic, Pusan National University Hospital, in March, 1969, because of nodular swelling in the right breast and in the left people. Her family and past histories were non-contributory. She had had good health until three years before, when she developed a spasm in both lower extremities. This spasm persisted intermittently for about three years and at that times small: nodule developed in the left people. About five days before her visiting this hospital, she had accidentally noticed another thumb-tip sized, painless nodule in the right breast. At that time of her visit physical examination revealed a few bean sized, soft, subcutaneous nodules in the upper lateral portion of the areola of the right breast and a firm, small egg sized, subcutaneous nodule in the inner aspect of the left people. They were non-tender, painless and movable. Clinically this case was suspected as breast cancer.
Histologicallly, the biopsy specimen of the nodules in the right breast showed the subcutaneous adipose tissue which was almost replaced by many granulomata consisting of numerous macrophages, many multinuclated giant cells, fibroblasts and occasional lymphocytes. The granulomata were separated by varying amounts of fibrous tissue composed of proliferating fibroblasts and reticulugi The macrophages had a round nucleus and abundant cytoplasm with granular or foamy to vacuolar appearance. Some of the giant cells had a few vacuoles in the their cytoplasm. The polymorphonuclear leukocytes were rather rare. On occasion, there were focal aggregations of lymphocytes often forming lymphoid tissues. No acid fast bacilli could be identified in the granulomatous tissue by Ziehi Neelson´ s technique. Characteristically there was seen no necrosis in the granulomatous reaction.
The histological features of the subcutaneous nodule of the left pople were quite similar to those observed in the subcutanous nodules of the right breast, except for more marked proliferation of fibroblast and more prominent diffuse infiltration of lymphocytes than the later.
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